Protein RELA map

Identifiers
HUGO:RELA
RELA proto-oncogene, NF-kB subunit
HUGO:RELA hgnc_id:HGNC:9955 HGNC:9955 ENTREZ:5970 UNIPROT:Q04206
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206
NFKB3 "nuclear factor of kappa light polypeptide gene enhancer in B-cells 3"
HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 GENECARDS:RELA REACTOME:65897 KEGG:5970 ATLASONC:RELAID325 WIKI:RELA

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / ER_STRESS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:8383323
The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.
PMID:15079071
In T cells the alternative NFkB pathway acts via RELA/p52 dimer not via RELB/p52 sownstream CD28
CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-??B subunits on IL-8 and Bcl-xL gene promoters
when T cells were stimulated with anti-CD3 antibody, RelA, c-Rel, and p50 were preferentially recruited to the IL-2 promoter
PMID:15536066
Signal-dependent nuclear translocation of p50 and p65 is impaired in PKC?????/??? cells.
PMID:23430059
PMID:19171876
NFkB signaling via RELA:p50 heterodimer provides
expression of proinflamatory cytokines and realisation
of M1 phenotype of macrophages.
PMID:17550372, PMID:9743347
IL13 inhibits NF??B activation via inhibition of p65 nuclear migration in inflammatory marophages

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. RELA@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  2. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  3. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  4. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map
  5. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  2. rRELA@INNATE_IMMUNE_CELL_Cytosol map → map RELA@INNATE_IMMUNE_CELL_Cytosol map
  3. CBP*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map → map CBP*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  4. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
  5. IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. NFKB1_p50*:​RELA:​p100@INNATE_IMMUNE_CELL_Cytosol map → map NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map + p100@INNATE_IMMUNE_CELL_Cytosol map
  7. NFKB1_p50*@INNATE_IMMUNE_CELL_Cytosol map + RELA@INNATE_IMMUNE_CELL_Cytosol map + IkB*@INNATE_IMMUNE_CELL_Cytosol map → map IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map