Identifiers
CREB binding protein, CBP
HUGO:CREBBP, HGNC:2348, ENTREZ:1387, UNIPROT:Q92793
HUGO:CREBBP
CREB binding protein
HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP
cAMP responsive element binding protein 3
HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3
cAMP responsive element binding protein 5
HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5
CBP KAT3A RTS
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_M_CHECKPOINT
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / HEDGEHOG
Survival / PI3K_AKT_MTOR
Survival / WNT_CANONICAL
References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:20144767
PMID:19879327
STAT1 is acetylated by CBP at the lysine residues K410 and K413.
PMID:16007092
GSK3B induces RELA (p65) interaction with CBP and activates downstream NF-kB signaling end expression of proinflammatory cytokines.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
IRF-1 can be acetylated by p300. p300 is recruited to the IL-12p40 promoter depending on both ICSBP and IRF-1
and acts as coactivator in macrophages.
PMID:17565603
PMID:15337521
CREB binding protein
References
in_re708( Innate Immunity ):
PMID:17689680
STAT1 acetilation inhibits its activity in macrophages.
PMID:19879327
Probably STAT1 is acetylated by CBP at the lysine residues K410 and K413.
+ RELA@INNATE_IMMUNE_CELL_Cytosol → CBP*:RELA@INNATE_IMMUNE_CELL_Cytosol
+ CBP*@INNATE_IMMUNE_CELL_Cytosol → CBP*:CREB1|pho@INNATE_IMMUNE_CELL_Cytosol
→ NFkB*@INNATE_IMMUNE_CELL_Cytosol
+ RELA@INNATE_IMMUNE_CELL_Cytosol → CBP*:RELA@INNATE_IMMUNE_CELL_Cytosol
→ STAT1|pho|ace@INNATE_IMMUNE_CELL_Cytosol
→ IRF1|ace@INNATE_IMMUNE_CELL_Cytosol