Identifiers
HUGO:CREB1
cAMP responsive element binding protein 1
HUGO:CREB1 HGNC:2345 ENTREZ:1385 UNIPROT:P16220
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production.
TLR activation of CREB by phosphorylation of serine-133 is dependent on p38.
PMID:16713974, PMID:11579131
INFG pathway inhibits activation (phosphorylation) of ERK, JNK, p38 kinases and PI3K pathway induced by TLR. Inhibition of AKT pathway by IFNG resulted in activation of GSK3. GSK3 inhibits downstream AP-1 and CREB1 signaling and downregulates IL10 expression induced by TLR.IFNG inhibits CREB activation via p38 induced by TLR signaling
CREB activation participates in the transcriptional activation of several immediate-early genes such as c-fos junB and egr1. MSK1 rather than RSK1 mediates the mitogen-stimulated phoshphorylation of CREB.
PMID:15187187
References
in_re1281( Innate Immunity ):
PMID:16713974
TLR activation of CREB by phosphorylation of serine-133 is dependent on p38.
GSK3B inhibits IL10 expression downstream of IFNG, probably via GREB1 inhibition.
PMID:16007092
GSK3B inhibits CREB1 interaction CBP and inhibits CREB1 dependent IL10 expression.
References
in_re1281( Innate Immunity ):
PMID:16713974
TLR activation of CREB by phosphorylation of serine-133 is dependent on p38.
GSK3B inhibits IL10 expression downstream of IFNG, probably via GREB1 inhibition.
PMID:16007092
GSK3B inhibits CREB1 interaction CBP and inhibits CREB1 dependent IL10 expression.
in_re423( Innate Immunity ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.