RNA PTGS2 map

Identifiers
HUGO:PTGS2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
CASCADE:IL1
PMID:20138012
PTGS2, CXCL1, and CXCL2; the proinflammatory cytokines IL-1?? and IL-6, CYR61 and OPN are upregulated in CAFs
PMID:21847358
IL-1?? was established as the initiator of the enhanced production of inflammatory factors through the binding of IL-1?? to IL-1 receptor 1 (IL-1R1) expressed predominantly by CAFs.
IL1A upregulates expression of IL6, CCL20, CXCL8, COX2 in CAFs.
IL-1?? Expression Levels in prostate cancer Tissue Correlated to
PMID:23390297
MIF inhitits expression of M1 markers such as TNF, IL12p40, COX2, INOS, IRF-5, MHC-II, CD11c, CD80, CD86 and MIF induces expression of M2 markers as IL10, stabilin-1, MRC-1, CD206, CD23

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. rPTGS2@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map rPTGS2@INNATE_IMMUNE_CELL_Cytosol map
    2. rPTGS2@INNATE_IMMUNE_CELL_Cytosol map → map PTGS2@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: