→ IkB*|pho:NFKB1_p50*:RELA@INNATE_IMMUNE_CELL_Cytosol References
PMID:15145317
The activated IKK complex,
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription.
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1..