IKBKG:IKK_alpha_*:IKK_beta

Complex IKBKG:IKK_alpha_*:IKK_beta_*

Complex composition:

IKBKG:IKK_alpha_*:IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:IKBKG:IKK_alpha_*:IKK_beta_*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS

References
complex
PMID???:15145317
The activated IKK complex,
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription
PMID:10521409, PMID:18802069
The endogenous IKK complex, overexpressed IKKs, and recombinant IKKbeta efficiently phosphorylated the Ser536 residue of p65 in vivo and in vitro,
that is important foe NFKB signaling activation.Ser536 is phoshorylated downstream of RAGE signaling in MDSC.
PMID:24766893
Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-??B and IRF3 through the kinases IKK and TBK1, respectively
in_re884( Innate Immunity ):
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.
PMID:21232017, PMID:21133840, PMID:17301840
PMID:24958845, PMID:24699077
The LUBAC complex ubiquitinates NEMO, a subunit of the IKK complex downstream of TNF and upregulates IkBa degradetion.
PMID:11280761
VEGF signaling blocs TNF-?? induced activation of I??B kinase (IKK complex).This decreased IKK activation correlated with the inhibition of I??B?? phosphorylation and degradation of I??B?? and I??B?? in HPCs, and this inhibition is inhdependent or FLT1 and KDR

IKBKG|ubi:IKK_beta_*|pho:MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:IKBKG:IKK_alpha_*:IKK_beta_*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS

References
complex
PMID???:15145317, PMID:15573129
The activated IKK complex,
catalyzes the phosphorylation of IkBs (at sites
equivalent to Ser32 and Ser36 of IkBa), polyubiquitination
(at sites equivalent to Lys21 and Lys22 of IkBa) and
subsequent degradation by the 26S proteasome. The
released NF-kB dimers (in this pathway, most commonly
the p50??? RelA dimer) translocate to the nucleus, bind DNA
and activate gene transcription
PMID:15573129
NF-B is required for the development of DCs
Blocking NF-B activity been shown to prevent DC differentiation from progenitor cells in vitro.
PMID:24766893
Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-??B and IRF3 through the kinases IKK and TBK1, respectively
PMID:11438547, PMID:24378531
in macrophages
Both TNFR1 and TNFR2 signaling pathways induce classical NFkB activation via IKBa degradation.
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.
in_re884( Innate Immunity ):
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.
PMID:21232017, PMID:21133840, PMID:17301840
PMID:24958845, PMID:24699077
The LUBAC complex ubiquitinates NEMO, a subunit of the IKK complex downstream of TNF and upregulates IkBa degradetion.
PMID:11280761
VEGF signaling blocs TNF-?? induced activation of I??B kinase (IKK complex).This decreased IKK activation correlated with the inhibition of I??B?? phosphorylation and degradation of I??B?? and I??B?? in HPCs, and this inhibition is inhdependent or FLT1 and KDR
in_re707( Innate Immunity ):
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.
in_re877( Innate Immunity ):
PMID:15145317
predominantly acting through IKKb in an IKKg-dependent
manner, catalyzes the phosphorylation of IkBs (at sites
PMID:17485448
IL10 Iinhibits IKBa??? ???phosphorylation and proteasomal degradation and prevents activation of downstream??? ???NFkB??? ???signaling.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: