Reaction state_transition in_re707 map

STAT1@INNATE_IMMUNE_CELL_Cytosol map → STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. IL15:​IL15RA:​IL2RB|​pho:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  2. IFNAR1:​IFNAR2:​JAK1:​TYK2@INNATE_IMMUNE_CELL_Membrane map
  3. IL21:​IL21R:​IL2RG:​JAK1|​pho:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  4. DAG:​PRKCQ|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
  6. CSF2:​CSF2RA:​CSF2RB:​JAK2|​pho@INNATE_IMMUNE_CELL_Membrane map
Inhibition
  1. IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map


References
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.