Complex IFNG:IFNGR1:IFNGR2:JAK1:JAK2 map
Complex composition:

  1. IFNGR1 map
  2. IFNGR2 map
  3. JAK1 map
  4. JAK2 map
  5. IFNG map

IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IFNG:IFNGR1:IFNGR2:JAK1:JAK2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:17683974
IFNG dimer binds to receptor contained two IFNGR1 and two IFNGR2 subunits.
PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2.
Ligand engagement of the IFNG receptor leads to activation of receptor-associated Jak1 and Jak2 and phosphorylation of a receptor tyrosine residue
(Y440) that serves as a docking site for STAT1, which exists in a latent state in the cytoplasm.
in_re707( Innate Immunity  map ):
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IFNG|​hm2@default map + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map