Protein IFNGR1 map

Identifiers
interferon gamma receptor 1
HUGO:IFNGR1 hgnc_id:HGNC:5439 HGNC:5439 ENTREZ:3459 UNIPROT:P15260
HUGO:IFNGR1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:17683974
IFNG dimer binds to receptor contained two IFNGR1 and two IFNGR2 subunits.

IFNGR1@INNATE_IMMUNE_CELL_Membrane

References
in_re692( Innate Immunity  map ):
PMID:22003200
IRF4 is a target of MIR125B1, inhibition of IRF4 by MIR125B1
resulted in increased surface expression of MHC II, CD40, CD86,
CD80 and IFNGR.
MIR125B potentiate response to IFNG, probably via
induction of IFNGR surface expression
and induces tumoricidal activity of macrophages.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IFNGR1@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map
  2. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IFNG|​hm2@default map + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
  2. IFNGR1@INNATE_IMMUNE_CELL_Membrane map + IFNGR2@INNATE_IMMUNE_CELL_Membrane map → map IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. STAT1@INNATE_IMMUNE_CELL_Cytosol map → map STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map