Reaction heterodimer_association in_re692 map

IFNGR1@INNATE_IMMUNE_CELL_Membrane map + IFNGR2@INNATE_IMMUNE_CELL_Membrane map → IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map

Reaction regulators:
Catalysis
  1. arMIR125B1@INNATE_IMMUNE_CELL_Cytosol map
Inhibition
  1. IRF4@INNATE_IMMUNE_CELL_Cytosol map


References
PMID:22003200
IRF4 is a target of MIR125B1, inhibition of IRF4 by MIR125B1
resulted in increased surface expression of MHC II, CD40, CD86,
CD80 and IFNGR.
MIR125B potentiate response to IFNG, probably via
induction of IFNGR surface expression
and induces tumoricidal activity of macrophages.