Identifiers
NAME:IL21:IL21R:IL2RG:JAK1:JAK3
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
NATURAL_KILLER
CASCADE:IL21
PMID:24751819
Interleukin-21 (IL-21) is produced by CD4+ T cell populations, with the highest production by T follicular helper (TFH) cells and TH17 cells, and slightly lower levels produced by natural killer T (NKT) cells.
IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the common cytokine receptor ??-chain, (encoded by IL2RG)
in_re163( Innate Immunity ):
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:10426994??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.
in_re707( Innate Immunity ):
PMID:12811837
TLR signaling can induces STAT1 phosphorylation via p38 and potentiate IFNG signaling.
PMID:19833085
STAT1 is activated downstream of IFNG by phosphorylation of tyrosine 701, translocates to the nucleus, binds to a regulatory DNA element termed gamma-activated sequence (GAS) and stimulates transcription of STAT1 target genes.
+ IL21R:IL2RG@INNATE_IMMUNE_CELL_Membrane + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK3@INNATE_IMMUNE_CELL_Cytosol → IL21:IL21R:IL2RG:JAK1|pho:JAK3@INNATE_IMMUNE_CELL_Membrane
→ PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
→ STAT1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ STAT3|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ STAT5*|pho@INNATE_IMMUNE_CELL_Cytosol