Protein IL21R
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity
/ IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
NATURAL_KILLER
CASCADE:IL21
PMID:24751819
Interleukin-21 (IL-21) is produced by CD4+ T cell populations, with the highest production by T follicular helper (TFH) cells and TH17 cells, and slightly lower levels produced by natural killer T (NKT) cells.
IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the common cytokine receptor ??-chain, (encoded by IL2RG)
Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
- IL21R@INNATE_IMMUNE_CELL_Membrane
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
- IL21R:IL2RG@INNATE_IMMUNE_CELL_Membrane
- IL21:IL21R:IL2RG:JAK1|pho:JAK3@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- IL2RG@INNATE_IMMUNE_CELL_Membrane
+ IL21R@INNATE_IMMUNE_CELL_Membrane
→
IL21R:IL2RG@INNATE_IMMUNE_CELL_Membrane
- IL21@default
+ IL21R:IL2RG@INNATE_IMMUNE_CELL_Membrane
+ JAK1@INNATE_IMMUNE_CELL_Cytosol
+ JAK3@INNATE_IMMUNE_CELL_Cytosol
→
IL21:IL21R:IL2RG:JAK1|pho:JAK3@INNATE_IMMUNE_CELL_Membrane
As Catalyser:- PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
→
PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
- STAT1@INNATE_IMMUNE_CELL_Cytosol
→
STAT1|pho|active@INNATE_IMMUNE_CELL_Cytosol
- STAT3@INNATE_IMMUNE_CELL_Cytosol
→
STAT3|pho|active@INNATE_IMMUNE_CELL_Cytosol
- STAT5*@INNATE_IMMUNE_CELL_Cytosol
→
STAT5*|pho@INNATE_IMMUNE_CELL_Cytosol