Reaction state_transition in_re163 map

PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map → PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. GAB2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. IL21:​IL21R:​IL2RG:​JAK1|​pho:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  3. SH2D1B|​pho:​SLAMF7|​pho|​hm2@INNATE_IMMUNE_CELL_Membrane map
  4. IL15@default map
  5. LGALS3:​SLC3A2@INNATE_IMMUNE_CELL_Membrane map
  6. CSF2@default map
  7. DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  8. SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Inhibition
  1. IFNG|​hm2@default map


References
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:10426994??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.