Identifiers
HUGO:IL15
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / TREG_MODULATORS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION
References
PMID:20007590
IL15 is important cytokine for tregs. Fibroblast could modulate Tregs by IL15 production.
DENDRITIC_CELL
NATURAL_KILLER
CASCADE:IFNAB
CASCADE:IL15
PMID:7523571
Interleukin 15 (IL-15) controls both the homeostasis and the peripheral activation of natural killer (NK).
Interleukin (IL) 15 activates human natural killer cells via components of the IL-2 receptor and induces cytoxic activity against tumor cells and participates in regulation of cytokine production.
PMID:17398124, PMID:19913445, PMID:17459805, PMID:21307131
Dendritic cells and macrophages prime natural killer cells by trans-presenting interleukin 15.
IL-15 is trans-presented on the surface of IL-15-producing cells in complex with the IL-15 receptor ?? chain (IL-15R??).
It results in tumoricidal activity of NK cells.
PMID:14607946
DCs activate resting NK cells by expressing MHC class I-related chain A and B (MICA/B), ligands for NKG2D, in response to IFN-alpha and IL15.
IL-15- and type I IFN-mediated induction of MICA/B in healthy donors is completely inhibited when DCs are incubated in the presence of anti-IFN-alpha/betaR or anti-IL-15Ralpha, respectively, suggesting interdependent roles of these cytokines in MICA/B expression. Indeed, DCs produced IL-15 in response to type I IFN, whereas they directly produced IFN-beta, in response to IL-15, which was followed by the production of IFN-alpha.
PMID:25582338
mIL-15 DCs secreted markedly greater amounts of proinflammatory cytokines, including IL-1??, IL-1??, IL-6, TNF??, TNF?? and IFN-??, compared with mIL-4 DCs, suggesting that mIL-15 DCs are more proinflammatory than mIL-4 DCs.
References
in_re163( Innate Immunity ):
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:10426994??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.
in_re826( Innate Immunity ):
PMID:10952726
HMGB1 induces expression of proinflammotory cytokine IL1A
in_re1234( Innate Immunity ):
CASCADE:IL15
CASCADE:IL21
CASCADE:IL12
NATURAL_KILLER
+ IL15RA@INNATE_IMMUNE_CELL_Membrane → IL15:IL15RA@INNATE_IMMUNE_CELL_Membrane
→ Antigen_presentation@default
→ IMMUNE_ACTIVATION@default
+ IL15@default + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK3@INNATE_IMMUNE_CELL_Cytosol → IL15:IL15RA:IL2RB|pho:IL2RG:JAK1:JAK3@INNATE_IMMUNE_CELL_Membrane
→ IL15@INNATE_IMMUNE_CELL_Cytosol
→ IL15@default
→ TNF@default
→ rTBX21@INNATE_IMMUNE_CELL_Cytosol
→ arMIR27A*@INNATE_IMMUNE_CELL_Cytosol
→ arMIR150@INNATE_IMMUNE_CELL_Cytosol
→ IL6@default
→ arMIR15/16*@INNATE_IMMUNE_CELL_Cytosol
→ rIL18R1@INNATE_IMMUNE_CELL_Cytosol
→ rIL18RAP@INNATE_IMMUNE_CELL_Cytosol
→ rIL12RB2@INNATE_IMMUNE_CELL_Cytosol
→ IFNB*@default
→ arMIR223@INNATE_IMMUNE_CELL_Cytosol
→ SP1@INNATE_IMMUNE_CELL_Cytosol
→ PI3KR(p85)*@INNATE_IMMUNE_CELL_Cytosol
→ ERK1/2*|pho@INNATE_IMMUNE_CELL_Cytosol
→ DAP12*@INNATE_IMMUNE_CELL_Membrane
→ rTGFBR2@INNATE_IMMUNE_CELL_Cytosol
→ rSMAD3@INNATE_IMMUNE_CELL_Cytosol
→ STAT1|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ trILB1@default
→ IL15@default
→ rMICA@INNATE_IMMUNE_CELL_Cytosol
→ rMICB@INNATE_IMMUNE_CELL_Cytosol
→ STAT3|pho|active@INNATE_IMMUNE_CELL_Cytosol
→ IL1A@INNATE_IMMUNE_CELL_Cytosol
→ rIL2RA@INNATE_IMMUNE_CELL_Cytosol
→ STAT5*|pho@INNATE_IMMUNE_CELL_Cytosol
→ IL2@default
→ STAT4|pho@INNATE_IMMUNE_CELL_Cytosol