Gene SMAD3 map

Identifiers
SMAD family member 3
"MAD, mothers against decapentaplegic homolog 3 (Drosophila)", MADH3, "SMAD, mothers against DPP homolog 3 (Drosophila)"
HUGO:SMAD3 HGNC:6769 ENTREZ:4088 UNIPROT:P84022
HUGO:SMAD3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS  map

References
CASCADE:TGFB
CASCADE:IL12
CASCADE:IL18
CASCADE:IL15
PMID:16713975
SMAD2, SMAD3 and SMAD4 participate in suppression of TBX21 (T-BET) promoter activity downstream of TGFB.
costimulation of NK cells with IL-12 and IL-18 or with IL12 and IL15 downregulated SMAD3 transcript and protein level.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. gSMAD3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSMAD3@INNATE_IMMUNE_CELL_Cytosol map → map rSMAD3@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: