Protein STAT4 map

Identifiers
HUGO:STAT4

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
 NATURAL_KILLER  map
CASCADE:IL12
CASCADE:IL2
CASCADE:IL15
PMID:10961885
Phosphorylation of tyrosine 693 and serine 721 is required for IL-12-induced STAT4 activation.
Expression of the S721A mutant reduced IL-12 induction of the reporter,
whereas mutation of serine 723 had no effect on STAT4-mediated transactivation.
Mutation of tyrosine 693 completely abolished IL-12???induced STAT4 transcriptional activity.
MKK6/p38, but not other MAPKs, enhance STAT4 transcriptional activity via Ser721 phosphorylation downstream of il12.
PMID:8700208, PMID:9715265, PMID:11449378, PMID:8683106
IL-12 and IFNA signaling induces STAT4 tyrosine phosphorylation. And induces IFNG production via binding of Stat4 to IFNG??? promoter GAS element.
PMID:12372421,
The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.
PMID:10807786
Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STAT4@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. STAT4|​pho|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. STAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map
    2. STAT4|​pho@INNATE_IMMUNE_CELL_Cytosol map → map STAT4|​pho|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
    3. rSTAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
    2. gPRF1@INNATE_IMMUNE_CELL_Cytosol map → map rPRF1@INNATE_IMMUNE_CELL_Cytosol map