Identifiers
HUGO:PRF1
References
NATURAL_KILLER
CASCADE:IL12
CASCADE:IL15
CASCADE:IFNAB
CASCADE:IL2
PMID:9841920
Induction of perforin mRNA by IL-2 and IL-15 was markedly decreased in Stat5b???/??? splenocytes
PMID:10544201, PMID:12372421
Perforin enhancers contain tandem Stat-like elements that are required for their IL-2 response and transactivation by Stat5.
PMID:10072525
STAT5a/b and not STAT3 were binding to the STAT element downstream of IL2.
IL-6 stimulation results in the detection of a complex on perforin promoter that can be blocked by the addition of anti-STAT1A antiserum.
PMID:12372421
Activated STAT1, STAT3, STAT4, and STAT5 bound human perforin promoter in vitro.
PMID:12133954
IL-2R signals can activate a pathway leading to NF-??B p50/p65 activation in NK cells, NF-??B binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression.
PMID:12967644
IFNA induces perforin expression via STAT1 in NK cells.
PMID:21960590
Human miR-27a* specifically bound to the 3' untranslated regions of Prf1 and GzmB, down-regulating expression in both resting and activated NK cells.
The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells
IL-2R signals can activate a pathway leading to NF-??B p50/p65 activation in NK cells, IL2R signaling induces IkBa degradation and formation of heterodimeric p50/p65 NFkB complexes, NF-??B binds to the upstream enhancer of the perforin gene and that this pathway is involved in the activation of perforin expression ().