Protein IL2 map

Identifiers
HUGO:IL2
HUGO:1L2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / TREG_MODULATORS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_EXPRESSION  map

References
PMID:1825141 PMID:2965306 PMID:26755705 PMID:18758473
PMID:22224781
L-2 is also required for TGF-??-mediated induction of Foxp3 in peripheral T cells in vitro
( but there are no data that it is expressed by fibroblast)
 NATURAL_KILLER  map
CASCADE:Fc_gamma_RIII
CASCADE:IL15
CASCADE:CD40LG
CASCADE:NKp30
PMID:6164929
IL2 has the ability to augment the cytotoxic activity of natural killer (NK) cells agains tumor cells
and potentiate effect of other cytokines (interferons).
PMID:15289500
Dendric cells-derived IL-2 induces NK cell activation.
DC-derived IL-2 Is Required In Vitro to Elicit IFN?? Production from NK Cells.
PMID:23650441
IL-2???treated NK cells had a significantly increased contact efficiency as determined by the number of target cell contacts that cells underwent before initiating Ca2+ flux for the first time
The ability of IL-2 to modulate NK cell cytotoxicity directly correlated with its ability to increase target???cell conjugation.
IL-2 rapidly increases NK cell adhesion to and killing of weak targets.
NK cell reactivity toward missing-self targets was enhanced in the absence of T reg cells and depended on the availability of IL-2 and activated T cells.
CD4+ T cell???derived IL-2 activated NK cells in the absence of T reg cells.
PMID:19528259
Nkp30??? ???signaling induces IL2??? ???release.
PMID:9625766
IL2??? ???stimulates NKp44??? ???surface expression in NK cells.
PMID:10807786
Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4
PMID:15563472
Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.
??15353479
Human and mouse DCs produce IL-2 downstream of IL15+CD40L signaling

IL2@default

References
in_re884( Innate Immunity  map ):
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.
PMID:21232017, PMID:21133840, PMID:17301840
PMID:24958845, PMID:24699077
The LUBAC complex ubiquitinates NEMO, a subunit of the IKK complex downstream of TNF and upregulates IkBa degradetion.
PMID:11280761
VEGF signaling blocs TNF-?? induced activation of I??B kinase (IKK complex).This decreased IKK activation correlated with the inhibition of I??B?? phosphorylation and degradation of I??B?? and I??B?? in HPCs, and this inhibition is inhdependent or FLT1 and KDR

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IL2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. IL2@default map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL2@INNATE_IMMUNE_CELL_Cytosol map → map IMMUNE_ACTIVATION@default map
  2. rIL2@INNATE_IMMUNE_CELL_Cytosol map → map IL2@INNATE_IMMUNE_CELL_Cytosol map
  3. IL2@default map + IL2RA:​IL2RB:​IL2RG@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK3@INNATE_IMMUNE_CELL_Cytosol map → map IL2:​IL2RA:​IL2RB:​IL2RG:​JAK1:​JAK3@INNATE_IMMUNE_CELL_Membrane map
  4. IL2@INNATE_IMMUNE_CELL_Cytosol map → map IL2@default map
As Catalyser:
  1. gTBX21@INNATE_IMMUNE_CELL_Cytosol map → map rTBX21@INNATE_IMMUNE_CELL_Cytosol map
  2. NKp44*@INNATE_IMMUNE_CELL_Cytosol map → map NKp44*@INNATE_IMMUNE_CELL_Membrane map
  3. WASF2@INNATE_IMMUNE_CELL_Cytosol map → map WASF2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. IL12RB2@INNATE_IMMUNE_CELL_Cytosol map → map IL12RB2@INNATE_IMMUNE_CELL_Cytosol map
  5. IL12RB1@INNATE_IMMUNE_CELL_Cytosol map → map IL12RB1@INNATE_IMMUNE_CELL_Cytosol map
  6. LTA@INNATE_IMMUNE_CELL_Cytosol map → map LTA@INNATE_IMMUNE_CELL_Cytosol map
  7. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  8. gSH2D1A@INNATE_IMMUNE_CELL_Cytosol map → map rSH2D1A@INNATE_IMMUNE_CELL_Cytosol map
  9. NKp46*@INNATE_IMMUNE_CELL_Cytosol map → map NKp46*@INNATE_IMMUNE_CELL_Membrane map
  10. KIR2DL4@INNATE_IMMUNE_CELL_Cytosol map → map KIR2DL4@INNATE_IMMUNE_CELL_Membrane map
  11. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  12. rSTAT4@INNATE_IMMUNE_CELL_Cytosol map → map STAT4@INNATE_IMMUNE_CELL_Cytosol map
  13. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_beta_*|​pho:​MHC_class_I*@INNATE_IMMUNE_CELL_Cytosol map