Protein LTA map

Identifiers
HUGO:LTA
lymphotoxin alpha (TNF superfamily, member 1)
HUGO:6709 HGNC:6709 ENTREZ:4049 UNIPROT:P01374??GENECARDS:GC06P031541

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / ACTIVATING_CHECKPOINTS  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:27192566
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
CASCADE:IL2
PMID:11823516
Human immature dendritic cells express on their cell surface four different cytotoxic TNF family ligands: TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis inducing ligand; while cancer cells express the corresponding death receptors. Disruptions of interactions between the four ligands expressed on DCs and corresponding death-signaling receptors expressed on cancer cells using specific Abs or R:Fc fusion proteins block the cytotoxic activity of DCs directed against cancer cells.
PMID:1281193
IL2 induces surface expression of LTA in NK cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. LTA@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. LTA@INNATE_IMMUNE_CELL_Cytosol map → map LTA@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: