Protein KIR2DL4 map

Identifiers
HUGO:KIR2DL4

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / MARKERS_NK  map

References
CASCADE:KIR2DL4
CASCADE:IL2
 NATURAL_KILLER  map
PMID:11994457, PMID:11513144, PMID:16287995, PMID:12055234
KIR2DL4 (CD158d) is an NK cell-activating receptor with inhibitory potential.
KIR2DL4 (CD158d) is a receptor for the nonclassical HLA-G.
HLA-G is normally expressed only on fetal-derived trophoblast cells that invade the maternal decidua in pregnant women.
But it is expressed by many tumor cells and probably provides tumor escape from NK killing.
PMID:11994457
Tyrosine-phosphorylated KIR2DL4 inhibits NK cytotoxixity. It inhibits the immunoreceptor tyrosine-based activation motif (ITAM)-dependent activation mediated by NKp46 or the ITAM-independent activation mediated by 2B4.
via binding and activation of SHP-2
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK 5directly demonstrated for KIR2DL3 only.
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4).
PMID:11489965, PMID:15778339
???KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein. It induces IFNG production via p38 but not cytotoxicity in resting NK cells.
PMID:15778339
IL2 stimulates surface expression of KIR2DL4 (2DL4.1)and NKp46
PMID:17100877
KIR2DL4 both contains a cytoplasmic ITIM and encodes a transmembrane arginine residue, through which it can associate with the Fc??R??-chain
KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein. It induces IFNG production but not cytotoxicity in resting NK cells

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. KIR2DL4@INNATE_IMMUNE_CELL_Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. KIR2DL4@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_NK
  1. KIR2DL4@MARKERS_NK map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. FCER1G:​HLA-G:​KIR2DL4|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. KIR2DL4@INNATE_IMMUNE_CELL_Membrane map + HLA-G@TUMOR_CELL_AS_INDUCTOR_Membrane map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map FCER1G:​HLA-G:​KIR2DL4|​pho@INNATE_IMMUNE_CELL_Membrane map
  2. KIR2DL4@INNATE_IMMUNE_CELL_Cytosol map → map KIR2DL4@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  3. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
  4. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
  5. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map