Protein HLA-G map

Identifiers
HUGO:HLA-G

References
CASCADE:KIR2DL4
CASCADE:LILRB1
 NATURAL_KILLER  map
PMID:11994457, PMID:11513144, PMID:16287995
KIR2DL4 (CD158d) is a receptor for the nonclassical HLA-G.
HLA-G is normally expressed only on fetal-derived trophoblast cells that invade the maternal decidua in pregnant women.
But it is expressed by many tumor cells and probably provides tumor escape from NK killing.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR_Membrane
  1. HLA-G@TUMOR_CELL_AS_INDUCTOR_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. HLA-G:​LILRB1@INNATE_IMMUNE_CELL_Membrane map
  2. FCER1G:​HLA-G:​KIR2DL4|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. HLA-G:​LILRB1@INNATE_IMMUNE_CELL_Membrane map → map TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR map
  2. KIR2DL4@INNATE_IMMUNE_CELL_Membrane map + HLA-G@TUMOR_CELL_AS_INDUCTOR_Membrane map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map FCER1G:​HLA-G:​KIR2DL4|​pho@INNATE_IMMUNE_CELL_Membrane map
  3. LILRB1@INNATE_IMMUNE_CELL_Membrane map + HLA-G@TUMOR_CELL_AS_INDUCTOR_Membrane map → map HLA-G:​LILRB1@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  3. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
  4. PTPN11@INNATE_IMMUNE_CELL_Cytosol map → map PTPN11@INNATE_IMMUNE_CELL_Cytosol map
  5. p38*@INNATE_IMMUNE_CELL_Cytosol map → map p38*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map