Protein LILRB1
Identifiers
HUGO:LILRB1
References
CASCADE:LILRB1
NATURAL_KILLER
PMID:15771571, PMID:10591185, PMID:9933109
LILRB1 binds with low af???nity to a conserved region in the
??3 domain of essentially all HLA class I glycoproteins, including HLA-A, -B,
-C, -E, -F, and -G. LILRB1 receptors on NK cells can suppress their activation (cytotoxicity) upon encountering HLA classI???bearing
targets (demonstrated for HLA-G, only).
Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
- LILRB1@INNATE_IMMUNE_CELL_Membrane
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
- HLA-G:LILRB1@INNATE_IMMUNE_CELL_Membrane
Participates in reactions:
As Reactant or Product:- HLA-G:LILRB1@INNATE_IMMUNE_CELL_Membrane
→
TUMOR_KILING@TUMOR_CELL_AS_EFFECTOR
- LILRB1@INNATE_IMMUNE_CELL_Membrane
+ HLA-G@TUMOR_CELL_AS_INDUCTOR_Membrane
→
HLA-G:LILRB1@INNATE_IMMUNE_CELL_Membrane
As Catalyser: