Complex 2B4*:CD48:SH2D1A map
Complex composition:

  1. SH2D1A map
  2. 2B4* map
  3. CD48 map

2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:2B4*:CD48:SH2D1A

References
CASCADE:KLRB1
CASCADE:KIR2DL1
CASCADE:KIR2DL4
CASCADE:2B4
PMID:10358138
Phosphorylated h2B4 recruits SH2D1A (SAP).
Association of SAP with h2B4 prevents recruitment of PTPN11 (SHP-2).
PMID:15169881, PMID:22683124
2B4 signaling induces phosphorylation of SHIP1,VAV1( (probably via LCP2),CBL.
This phosphorylation is dependent on SAP and FYN.
2B4-evoked tyrosine phosphorylation of Vav-1 was nearly abolished in SAP-deficient and SAP R78A NK cells

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. CD48@INNATE_IMMUNE_CELL_Membrane map + 2B4*@INNATE_IMMUNE_CELL_Membrane map + SH2D1A@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
  2. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. 3BP2*@INNATE_IMMUNE_CELL_Membrane map → map 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map