Protein 3BP2* map

Identifiers
HUGO:SH3BP2

References
 NATURAL_KILLER  map
CASCADE:2B4
PMID:11390470, PMID:16177062
SH3BP2 (3BP2) is involevd in NK-activation. 3BP2 is coupled to activating receptors on NK cells.It is phosphorylated after NK stimulation.
CD244 ligation induces 3BP2 phosphorylation and Vav recruitment.
The adaptor protein 3BP2 binds human 2B4 (CD244) and links this receptor to Vav signaling, PLCG, ERK activation, and NK cell killing.
SH2 domain of 3BP2 is required for optimal tyrosine phosphorylation of 3BP2 following FcR cross-linking and for its ability to associate with the transmembrane adaptor protein LAT.
Phosphorylated tyrosine-183 of 3BP2 binds PLCG1 and PLCG2 and Vav1 during activation of NK cells through natural cytotoxicity receptors.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. 3BP2*@INNATE_IMMUNE_CELL_Membrane map
  2. 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. 3BP2*@INNATE_IMMUNE_CELL_Membrane map → map 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map
  2. 2B4*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map + 3BP2*|​pho@INNATE_IMMUNE_CELL_Membrane map → map 2B4*|​pho:​3BP2*|​pho:​CD48:​SH2D1A@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. LCP2@INNATE_IMMUNE_CELL_Cytosol map → map LCP2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. PLCG2@INNATE_IMMUNE_CELL_Cytosol map → map PLCG2|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. PLCG1@INNATE_IMMUNE_CELL_Cytosol map → map PLCG1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. CBL@INNATE_IMMUNE_CELL_Cytosol map → map CBL|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. LAT|​pho@INNATE_IMMUNE_CELL_Cytosol map → map LAT@INNATE_IMMUNE_CELL_Cytosol map
  6. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map