Identifiers
HUGO:PLCG1
phospholipase C gamma 1
"phospholipase C gamma 1 (formerly subtype 148)" PLC1
HUGO:PLCG1 HGNC:9065 ENTREZ:5335 UNIPROT:P19174
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CORE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:11532940
PMID:1712101 PMID:25456276 PMID:10811803 PMID:9846483 PMID:15214048 PMID:14764585 PMID:11994416 PMID:26552706
CASCADE:GAST
CASCADE:PDGF
PMID:7682895; PMID:17397400
PDGF -receptor directly binds and activates PLC-gamma 1, RasGAP, P13K, and a 64 kd protein.
PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts downstream of PDGF signaling
PMID:23523669; PMID:24584707
Prorastin induces fibroblast activation via PKC and PI3K pathways; probably
PKC is activated downstream of PLCG.
PMID:24584707
A dominant and early event triggered by gastrin binding to its receptors on target cells is activation of the PLC signaling pathway.
The involvement of the PLC pathway in promoting gastrin???s effects has been defined in
NIH3T3 fibroblasts expressing the CCKB/gastrin receptor [130], Rat1 fibroblasts transfected with the CCKB/gastrin receptor (Rat1CCKBR1) [108],
Receptor activation of PLC induces the breakdown of membrane phosphatidylinositol4,5-bisphosphate (PIP2), leading to the formation of two second messengers, IP3 and 1,2-diacylglycerol (DG) [6] and [88]. IP3 induces Ca2+ release from the internal storage pool [6], or probably affects membrane ion channels [57], and DG activates the protein kinase C (PKC) enzyme system
NATURAL_KILLER
MACROPHAGE
MAST_CELL
CASCADE:IL13
CASCADE:SLAMF7
CASCADE:2B4
CASCADE:Fc_gamma_RI
CASCADE:Fc_gamma_RII
CASCADE:Fc_gamma_RIII
CASCADE:IFNAB
PMID:25960930
IFN?? induces PKC-?? auto-phosphorylation in NK cells via P3K and PLC pathways and improves the degranulation via PKC-?? signaling
PMID:11169415, PMID:10072481, PMID:8649391
Tyrosine phosphorylation of LAT led to the recruitment of intracytoplasmic signaling molecules including phospholipase Cgamma and Grb2
and activation of phosphatidylinositol pathway in NK cells.
PMID:2536067, PMID:1281218
Ligation of??Fc gamma RIII alpha (CD16) ??induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells and stimulates expression of many cytokines via??Ca('2+)??-depend mechanism.
PMID:8226994
Stimulation of the human monocytic cell line THP-1 by cross-linking either Fc gamma receptor I (Fc gamma RI) or Fc gamma receptor II (Fc gamma RII) gave rise to the rapid phosphorylation of multiple intracellular proteins. The pattern of proteins that were phosphorylated appeared to be identical. Analysis of these proteins by specific immunoprecipitation indicated that stimulation through either receptor did indeed give rise to phosphorylation of the same set of proteins. These included: Fc gamma RII, phospholipase C (PLC) gamma 1, PLC gamma 2, Vav, GAP
PMID:10781611
The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells.
Co-immunoprecipitation experiments revealed a constitutive association of p36 LAT with both FcgammaRI and FcgammaRIIa immunoprecipitates, and an activation-induced association of LAT with PLCgamma1, Grb2, and the p85 subunit of phosphatidylinositol 3-kinase.
bone marrow-derived macrophages from LAT-deficient mice displayed reduced phagocytic efficiency in comparison to the macrophages from wild-type mice.
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616, PMID:10925299
PCL (probably PCLG1) induces hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+ release downstream of IL13. Intracellular Ca2+ release??release induces cAMP Accumulation in Human monocytes and activation of PKA signaling downstream of IL13.
PMID:7890616
IL13 inhibits ROI production downstream of cAMP/PKA in all macrophage types
PMID:19909365
The phosphorylation of LAT1
together with the generation of PIP3 in the lipid raft environment recruits proteins such as
PLC-??1 and PLC-??2
In response to Src-dependent activation of PLCG1 RasGRP1 translocated to the Golgi where it activated Ras.
PMID:12845332
References
in_re181( Innate Immunity ):
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616
PCL (probably PCLG1) induces t hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+??release downstream of IL13.
References
in_re181( Innate Immunity ):
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:7890616
PCL (probably PCLG1) induces t hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+??release downstream of IL13.