Simple molecule IP3 map
IP3@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:18287025
PLCG is upstream of JNK in the pathway of NKG2D-mediated cytotoxicity
PMID:20189481
PLCG inhibitor completely abrogated synergistic Erk phosphorylation downstream of NKG2D and 2B4.
These data suggest that PLCG, rather than PI3K, is a critical upstream regulator of Erk activation in this pathway.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. IP3@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: Endoplasmic Reticulum
  1. IP3:​IP3R*@Endoplasmic Reticulum map
Participates in reactions:
As Reactant or Product:
  1. IP3@INNATE_IMMUNE_CELL_Cytosol map + IP3R*@Endoplasmic Reticulum map → map IP3:​IP3R*@Endoplasmic Reticulum map
  2. PI4,5-P2@INNATE_IMMUNE_CELL_Cytosol map → map DAG@INNATE_IMMUNE_CELL_Cytosol map + IP3@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. ERK1/2*@INNATE_IMMUNE_CELL_Cytosol map → map ERK1/2*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  2. Ca2+@Endoplasmic Reticulum map → map Ca2+@INNATE_IMMUNE_CELL_Cytosol map