Ion Ca2+ map
Ca2+@Endoplasmic Reticulum

References
 MACROPHAGE  map
 NATURAL_KILLER  map
CASCADE:IL13
CASCADE:SLAMF7
CASCADE:NKP80
CASCADE:NKG2D
CASCADE:KIR2DS4
CASCADE:Fc_gamma_RIII
CASCADE:CR1
PMID:16204312
Calcium influx is an early event during perforin-mediated cytotoxicity.
PMID:12740575, PMID:15972651
NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.
Calcium influx is an early event during perforin-mediated cytotoxicity. PLC-??2 is absolutely required to regulate degranulation of cytotoxic perforin granules.
PMID:22683124
PLCG2-deficient NK cells displayed a partial reduction of conjugate formationwith target tumor cells probably via regulation of Ca2+ fluxes,
because a chelator of intracellular Ca2+ also provokes a partial reduction of conjugate formation.
PMID:11265639
Cross-linking of NKp80 induces Ca 2+ mobilization and
triggering of cytotoxicity in both resting and activated NK cells.
PMID:2536067, PMID:1281218
Ligation of??Fc gamma RIII alpha (CD16) ??induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells and stimulates expression of many cytokines via??Ca('2+)??-depend mechanism.
PMID:7890616, PMID:10925299
PCL (probably PCLG1) induces hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+ release downstream of IL13. Intracellular Ca2+ release??release induces cAMP Accumulation in Human monocytes and activation of PKA signaling downstream of IL13.
in_re177( Innate Immunity  map ):
In NK cells NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.

Ca2+@INNATE_IMMUNE_CELL_Cytosol

References
CASCADE:Fc_gamma_RIII
 NATURAL_KILLER  map
PMID:16204312
Calcium influx is an early event during perforin-mediated cytotoxicity.
PMID:12740575, PMID:15972651
NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.
Calcium influx is an early event during perforin-mediated cytotoxicity. PLC-??2 is absolutely required to regulate degranulation of cytotoxic perforin granules.
PMID:22683124
PLCG2-deficient NK cells displayed a partial reduction of conjugate formationwith target tumor cells probably via regulation of Ca2+ fluxes,
because a chelator of intracellular Ca2+ also provokes a partial reduction of conjugate formation.
PMID:10089876, PMID:7650486, PMID:9973469
??Ca('2+)??activates Calmodulin 2 (??Calmodulin??)/ Protein phosphatase 3 (Calcineurin??) signal. Activated??Calcineurin??dephosphorylates Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2 (??NF-AT1(NFATC2)??).??
(PMID10089876). This signaling is activated downstream of CD16
in_re177( Innate Immunity  map ):
In NK cells NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.
in_re1( Innate Immunity  map ):
PMID:10837075
Immature DCs are very efficient in Ag capture and can use several pathways, such as (a) macropinocytosis; (b) receptor-mediated endocytosis via C-type lectin receptors (mannose receptor, DEC-205)
or Fc?? receptor types I (CD64) and II (CD32) [uptake of immune complexes or opsonized particles ]; and (c) phagocytosis of particles such as latex beads , apoptotic and necrotic cell fragments (involving CD36 and ??v??3 or ??v??5 integrins), viruses, and bacteria including mycobacteria, as well as intracellular parasites such as Leishmania major. DCs can also internalize the peptide loaded heat shock proteins gp96 and Hsp70 through presently unknown mechanisms
in_re1145( Innate Immunity  map ):
PMID:7890616
Intracellular Ca2+??release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.

Modifications:
In compartment: Endoplasmic Reticulum
  1. Ca2+@Endoplasmic Reticulum map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Ca2+@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
  2. CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Ca2+@INNATE_IMMUNE_CELL_Cytosol map → map EXOCYTOSIS_AND_PHAGOCYTOSIS@INNATE_IMMUNE_CELL_Membrane map
  2. Ca2+@Endoplasmic Reticulum map → map Ca2+@INNATE_IMMUNE_CELL_Cytosol map
  3. Ca2+@INNATE_IMMUNE_CELL_Cytosol map → map Conjugate_formation@INNATE_IMMUNE_CELL_Membrane map
  4. Ca2+@INNATE_IMMUNE_CELL_Cytosol map + Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map → map Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
  5. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map + CNA*:​CNB*@INNATE_IMMUNE_CELL_Cytosol map → map CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Tumor_antigen@TUMOR_CELL_AS_EFFECTOR map → map Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. ATP@INNATE_IMMUNE_CELL_Cytosol map → map cAMP@INNATE_IMMUNE_CELL_Cytosol map
  3. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map NFAT*@INNATE_IMMUNE_CELL_Cytosol map
  4. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  5. gNFAT*@INNATE_IMMUNE_CELL_Cytosol map → map rNFAT*@INNATE_IMMUNE_CELL_Cytosol map