Reaction transport in_re177 map

Ca2+@Endoplasmic Reticulum map → Ca2+@INNATE_IMMUNE_CELL_Cytosol map

Reaction regulators:
Catalysis
  1. HLA-C:​KIR2DS4@INNATE_IMMUNE_CELL_Membrane map
  2. CR1@INNATE_IMMUNE_CELL_Membrane map
  3. IP3:​IP3R*@Endoplasmic Reticulum map
  4. (CLEC2B:​NKp80*|​pho|​hm2)|​active@INNATE_IMMUNE_CELL_Membrane map


References
PMID:12740575, PMID:15972651
In NK cells NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.