Identifiers
NAME:IP3:IP3R*
Maps_Modules
Innate Immunity / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS
References
MACROPHAGE
PMID:7890616
PCL (probably PCLG1) induces t hydrolysis of phosphoinositides and activates InsP3-induced intracellular Ca2+??release downstream of IL13.
in_re177( Innate Immunity ):
PMID:12740575, PMID:15972651
In NK cells NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.