Identifiers
NAME:CLEC2B:NKp80*
References
CASCADE:NKP80
NATURAL_KILLER
PMID:20663776, PMID:17057721
C-type lectin (AICL) is a unique KLRF1 ligand expressed on tumor cell lines of hematopoietic and non-hematopoietic origins.
PMID:20663776
Blocking of CLEC2B (AICL) partially inhibits NK cell degranulation (LAMP1/CD107a presentation).
PMID:11265639
Nkp80 signaling pathway induces Ca2+ mobilization and NK cell-mediated cytolytic activity.
Identifiers
NAME:CLEC2B:NKp80*
References
CASCADE:NKP80
NATURAL_KILLER
PMID:20663776, PMID:17057721
C-type lectin (AICL) is a unique KLRF1 ligand expressed on tumor cell lines of hematopoietic and non-hematopoietic origins.
PMID:20663776
Blocking of CLEC2B (AICL) partially inhibits NK cell degranulation (LAMP1/CD107a presentation).
PMID:11265639
Nkp80 signaling pathway induces Ca2+ mobilization and NK cell-mediated cytolytic activity.
in_re160( Innate Immunity ):
PMID:20814939, PMID:12731048
Phosphorylation of the ITAM sequence in the associated partner chains induces binding and phosphorylation of tyrosine kinases Syk and ZAP70 to the ITAM downstream of NKp30 or NKp46 or NKp44
in_re177( Innate Immunity ):
PMID:12740575, PMID:15972651
In NK cells NKG2D signaling inducese PLCG2 phosphorylation and Ca2+ release. ??The calcium signal generated by PLCG??is required for NKG2D-initiated killing.