Protein NKp80* map

Identifiers
HUGO:KLRF1

References
CASCADE:NKP80
 NATURAL_KILLER  map
PMID:11265639
Nkp80 is expressed at the NK cell surface as a dimer.
PMID:21149606, PMID:23609447
Tyrosine 7 of NKp80 is phosphorylated by Src kinases (probably by LCK) and required for NK cytotoxicity.
Cross-linking of NKp80 induces Ca 2+ mobilization and
triggering of cytotoxicity in both resting and activated NK cells.
PMID:21149606
Nkp80 signaling induces marked IFNG production

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. NKp80*|​hm2@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CLEC2B:​NKp80*|​hm2@INNATE_IMMUNE_CELL_Membrane map
  2. (CLEC2B:​NKp80*|​pho|​hm2)|​active@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. NKp80*|​hm2@INNATE_IMMUNE_CELL_Membrane map + CLEC2B@TUMOR_CELL_AS_INDUCTOR_Membrane map → map CLEC2B:​NKp80*|​hm2@INNATE_IMMUNE_CELL_Membrane map
  2. CLEC2B:​NKp80*|​hm2@INNATE_IMMUNE_CELL_Membrane map → map (CLEC2B:​NKp80*|​pho|​hm2)|​active@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. IFNG@INNATE_IMMUNE_CELL_Cytosol map → map IFNG@default map
  2. SYK@INNATE_IMMUNE_CELL_Cytosol map → map SYK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. Ca2+@Endoplasmic Reticulum map → map Ca2+@INNATE_IMMUNE_CELL_Cytosol map