Identifiers
HUGO:SYK
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:21378271
NATURAL_KILLER
MACROPHAGE
MAST_CELL
DENDRITIC_CELL
CASCADE:NKP80
CASCADE:NKG2A
CASCADE:KIR2DS2
CASCADE:KLRC2
CASCADE:NKP44
CASCADE:NKP46
CASCADE:NKP30
CASCADE:FCER
CASCADE:FCAR
CASCADE:Fc_gamma_RI
CASCADE:Fc_gamma_RII
CASCADE:Fc_gamma_RIII
PMID:10358164
CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells.
PMID:9396765
Syk-dependent signaling plays a critical role in NK cytotoxicity.
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:21149606, PMID:23609447
Syk kinase is part of the NKp80-signaling pathway, and phosphorylation of Syk requires integrity of the Y7-containing motif of NKp80.
NKp80 activates PI33/ERK pathway probably via SYK.
PMID:21910624
The event that follows Fc??R phosphorylation by Src-family kinases involves the spleen tyrosine kinase (Syk) (Figure 1). Syk displays two Src homology 2 (SH2) domains, which bind doubly phosphorylated ITAMs (43). This cytosolic kinase is expressed mostly in hematopoietic cells and becomes activated by phosphorylation upon Fc??R cross-linking (43, 44)
PMID:8226994, PMID:9314552, PMID:9632805, PMID:8189062
tyrosine kinase Syk associates with Fc??RII ((10)) and with the tyrosine phosphorylated ?? chain of Fc??RI ((11)) and Fc??RIII ((12)), and has been implicated in Fc??R-mediated phagocytosis.
Studies in macrophages from syk???/??? mice demonstrated that Syk is required for Fc??R-mediated phagocytosis
Syk-deficient macrophages were defective in phagocytosis induced by FcgammaR but showed normal phagocytosis in response to complement.
PMID:8189062
Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.
PMID:8226994
Stimulation of the human monocytic cell line THP-1 by cross-linking either Fc gamma receptor I (Fc gamma RI) or Fc gamma receptor II (Fc gamma RII) gave rise to the rapid phosphorylation of multiple intracellular proteins. The pattern of proteins that were phosphorylated appeared to be identical. Analysis of these proteins by specific immunoprecipitation indicated that stimulation through either receptor did indeed give rise to phosphorylation of the same set of proteins. These included: Fc gamma RII, phospholipase C (PLC) gamma 1, PLC gamma 2, Vav, GAP
PMID:12524384
FCAR induces SYK activation
PMID:9000133
Stimulation of Fc epsilon RI results in the rapid association and activation of the Syk tyrosine kinase. Using Syk-deficient mast cells we show that they fail to degranulate, synthesize leukotrienes and secrete cytokines when stimulated through Fc epsilon RI, conclusively demonstrating an essential role for Syk in Fc epsilon RI signalling.
PMID:19909365
Syk is adaptor protein f Fc epsilon RI signaling in mast cells
References
in_re160( Innate Immunity ):
NATURAL_KILLER
PMID:20814939, PMID:12731048
Phosphorylation of the ITAM sequence in the associated partner chains induces binding and phosphorylation of tyrosine kinases Syk and ZAP70 to the ITAM downstream of NKp30 or NKp46 or NKp44
References
in_re160( Innate Immunity ):
NATURAL_KILLER
PMID:20814939, PMID:12731048
Phosphorylation of the ITAM sequence in the associated partner chains induces binding and phosphorylation of tyrosine kinases Syk and ZAP70 to the ITAM downstream of NKp30 or NKp46 or NKp44
in_re163( Innate Immunity ):
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:10426994??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.