Protein Actin cytoskeletal* map

Identifiers
HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133 GENECARDS:ACTA1 HUGO:ACTA2 HGNC:130 ENTREZ:59 UNIPROT:P62736 GENECARDS:ACTA2 HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB HUGO:ACTC1 HGNC:143 ENTREZ:70 UNIPROT:P68032 GENECARDS:ACTC1 HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261 GENECARDS:ACTG1
actin, alpha 1, skeletal muscle
HUGO:ACTA1 hgnc_id:HGNC:129 HGNC:129 ENTREZ:58 UNIPROT:P68133
DSN1 homolog, MIS12 kinetochore complex component
HUGO:DSN1 hgnc_id:HGNC:16165 HGNC:16165 ENTREZ:79980 UNIPROT:Q9H410
actin, alpha 2, smooth muscle, aorta
HUGO:ACTA2 hgnc_id:HGNC:130 HGNC:130 ENTREZ:59 UNIPROT:P62736
actin beta
HUGO:ACTB hgnc_id:HGNC:132 HGNC:132 ENTREZ:60 UNIPROT:P60709
actin, alpha, cardiac muscle 1
HUGO:ACTC1 hgnc_id:HGNC:143 HGNC:143 ENTREZ:70 UNIPROT:P68032
actin gamma 1
HUGO:ACTG1 hgnc_id:HGNC:144 HGNC:144 ENTREZ:71 UNIPROT:P63261
HUGO:ACTA1, HUGO:ACTA2, HUGO:ACTB, HUGO:ACTC1, HUGO:ACTG1, HUGO:ACTG2
Actin cytoskeletal*
ACTA
HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133
HUGO:ACTA2 HGNC:130 ENTREZ:59 UNIPROT:P62736
HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709
ACTC, "actin, alpha, cardiac muscle"
HUGO:ACTC1 HGNC:143 ENTREZ:70 UNIPROT:P68032
ACTG, "deafness, autosomal dominant 20; deafness, autosomal dominant 26", DFNA20, DFNA26
HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261
NEM3, "nemaline myopathy type 3"
HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133 GENECARDS:ACTA1 REACTOME:49626 KEGG:58 ATLASONC:GC_ACTA1 WIKI:ACTA1
HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB
HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261 GENECARDS:ACTG1 REACTOME:49603 KEGG:71 ATLASONC:GC_ACTG1 WIKI:ACTG1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:18802007 PMID:23620508 PMID:26552706
REACTOME:49626 KEGG:58 ATLASONC:GC_ACTA1 WIKI:ACTA1
REACTOME:49566 KEGG:59 ATLASONC:GC_ACTA2 WIKI:ACTA2
REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB
REACTOME:49595 KEGG:70 ATLASONC:GC_ACTC1 WIKI:ACTC1
REACTOME:49603 KEGG:71 ATLASONC:GC_ACTG1 WIKI:ACTG1
CASCADE:PDGF
GASCADE:TGFB
CASCADE:EGF
CASCADE:HH
CASCADE:CXCL12
PMID:25732845 PMID:16139227
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression, probably via regulation of fibroblast migration.
Phosphorylation of Girdin by Akt Is Required for Cell Migration.
Girdin Is Required for the Formation of Actin Stress Fibers and Cell Migration
PMID:18423981
Opposing roles of EGF and TGF-?? on F-actin reorganization and Rho- GTPase activity
EGF treatment stimulated the bi-polarization and formation of dendritic-like cellular extensions of fibroblasts.
TGF-?? treatment, with reduction of polarized iHDFs from 40% to 12% and upregulation of stress fiber-positive fibroblasts from 30% to 84%.
PMID:20535745
CXCR4 receptor and CXCL12 both are expressed in fibroblasts and probably provides positive loop in fibroblast activation
and promotes RhoA-activation aand actin polymerisation.
PMID:26711338
CAFs Have Enhanced Actin and Septin Cytoskeletal Networks regulated by Cdc42EP3/BORG2
 DENDRITIC_CELL  map
 NATURAL_KILLER  map
 MACROPHAGE  map
PMID:18802007
Disruption of actin polymerization inhibits the up-regulation of surface MHCII in a dose-dependent manner in DC.
 MAST_CELL  map
CASCADE:CR3
CASCADE:Fc_gamma_RII
CASCADE:IL2
PMID:11766992
Fractalkine via CX3CR1 induces chemotaxis and migration associated actin polymerization in immature as well as in mature DCs.
PMID:9314552, PMID:8570922 , PMID:19741094
Actin is likely to play an important role in phagocytosis since it is concentrated in the macrophage cytoplasm surrounding the particle being engulfed, and since cytochalasin D treatment, which blocks actin polymerization, abrogates phagocytosis without affecting particle binding
PMID:9314552
Syk- macrophages exhibited formation of polymerized actin structures opposing particles bound to the cells by FcgammaRs (actin cups), but failed to proceed to internalization. Interestingly, inhibitors of phosphatidylinositol 3-kinase also blocked FcgammaR-mediated phagocytosis at this stage. Thus, PI 3-kinase may participate in a Syk-dependent signaling pathway critical for FcgammaR-mediated phagocytosis.
PMID:19909365
The Ca2+ influx is an essential trigger for fusion of the Mast Cell granules to the
membrane and the breakdown of the actin cytoskeleton.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map
  2. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
    2. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin polymerization@INNATE_IMMUNE_CELL_Cytosol map
    3. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map
    4. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
    5. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin_polymerization@INNATE_IMMUNE_CELL_Cytosol map
    6. Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser: