Maps_Modules
Innate Immunity / DANGER_SIGNAL_PATHWAYS
References
DENDRITIC_CELL
MACROPHAGE
CASCADE:STING
CASCADE::P2RX7
CASCADE::P2RY2
PMID:20086177
ATP was released by tumor cells succumbing to chemotherapy. ATP activates purinergic P2RX7 receptors on DC, thus activating the NLRP3/ASC/caspase-1 inflammasome and driving the secretion of interleukin-1beta (IL-1beta). IL-1beta then is required for the adequate polarization of IFNgamma-producing CD8(+) T cells.
PMID:19741708
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
UTP and ATP act via P2RY2 and promote P2Y(2)-dependent recruitment of phagocytes, and provide evidence for a clear relationship between a find-me signal and efficient corpse clearance in vivo.
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity / DANGER_SIGNAL_PATHWAYS
References
DENDRITIC_CELL
MACROPHAGE
CASCADE:STING
CASCADE::P2RX7
CASCADE::P2RY2
PMID:20086177
ATP was released by tumor cells succumbing to chemotherapy. ATP activates purinergic P2RX7 receptors on DC, thus activating the NLRP3/ASC/caspase-1 inflammasome and driving the secretion of interleukin-1beta (IL-1beta). IL-1beta then is required for the adequate polarization of IFNgamma-producing CD8(+) T cells.
PMID:19741708
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
UTP and ATP act via P2RY2 and promote P2Y(2)-dependent recruitment of phagocytes, and provide evidence for a clear relationship between a find-me signal and efficient corpse clearance in vivo.
in_re1145( Innate Immunity ):
PMID:7890616
Intracellular Ca2+??release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.