Protein P2RX7 map

Identifiers
HUGO:P2RX7

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
 DENDRITIC_CELL  map
CASCADE::P2RX7
PMID:20086177
ATP was released by tumor cells succumbing to chemotherapy. ATP activates purinergic P2RX7 receptors on DC, thus activating the NLRP3/ASC/caspase-1 inflammasome and driving the secretion of interleukin-1beta (IL-1beta). IL-1beta then is required for the adequate polarization of IFNgamma-producing CD8(+) T cells.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. P2RX7@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ATP:​P2RX7@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. ATP@default map + P2RX7@INNATE_IMMUNE_CELL_Membrane map → map ATP:​P2RX7@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map