Complex Caspase1*:NLRP3:PYCARD map
Complex composition:

  1. NLRP3 map
  2. PYCARD map
  3. Caspase1* map

Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol

Identifiers
NAME:Caspase1*:NLRP3:PYCARD

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / TUMOR_GROWTH  map

References
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
CASCADE:P2RX7
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3)
PMID:23202296
(Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1?? (IL-1??), which curtails anticancer immunity.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: