Protein Caspase1* map

Identifiers
caspase 1, apoptosis-related cysteine peptidase
"caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)", "caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)", IL1BC
HUGO:CASP1 HGNC:1499 ENTREZ:834 UNIPROT:P29466
caspase 1
HUGO:CASP1 hgnc_id:HGNC:1499 HGNC:1499 ENTREZ:834 UNIPROT:P29466

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / PYROPTOSIS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:11989976
PMID:17959595
Caspase1,3 promote proteosomal degradation of ARHGDIB
PMID:26885855
PMID:27048821
PMID:27066895
PMID:27984721
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
CASCADE:P2RX7
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3).After 2 hours of incubation, monocytes display clear activation of caspase-1 regardless of LPS stimulation.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: