Protein PYCARD map

Identifiers
PYD and CARD domain containing
HUGO:PYCARD HGNC:16608 ENTREZ:29108 UNIPROT:Q9ULZ3
synonyms:ASC

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / PYROPTOSIS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:26885855
PMID:27048821
PMID:27066895
PMID:27984721
Upon detection of their respective agonists, NLRP3, NLRC4, NLRP1b, AIM2, and pyrin assemble canonical inflammasomes containing adaptor ASC and leading to the activation of caspase-1 that controls the maturation of pro-cytokines (pro-IL-1b and pro-IL-18) and pyroptosis through the cleavage of GSDMD among other mechanisms.
 MACROPHAGE  map
 MDSC  map
 DENDRITIC_CELL  map
CASCADE:P2RX7
CASCADE:TLR2_4
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3)

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map
  2. (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. IL1B@INNATE_IMMUNE_CELL_Cytosol map → map trILB1@INNATE_IMMUNE_CELL_Cytosol map