Identifiers
HUGO:ILB1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
Innate Immunity / TUMOR_GROWTH
References
MACROPHAGE
MDSC
DENDRITIC_CELL
MAST_CELL
CASCADE:P2RX7
CASCADE:TLR2_4
CASCADE:IL15
CASCADE:IL1
PMID:19104081
Inflammasome is needfull for processing and release of IL-1beta in monocytes downstream of TLR2 or TLR4 signaling.
It contains CASP1, Pycard, NLRP3 (NALP3)
PMID:23202296
(Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1?? (IL-1??), which curtails anticancer immunity.
PMID:24727385
Tumor-derived IL-1?? secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC that promotes tumor growth.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
mRNA expression of several NF-??B target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-1R???deficient mice have a delayed accumulation of MDSC and reduced primary and metastatic tumor progression. Accumulation of MDSC and tumor progression are partially restored by IL-6, indicating that IL-6 is a downstream mediator of the IL-1?????induced expansion of MDSC. IL-1Ra (IL-1R antagonis) ???/??? MDSC are more suppressive than BALB/c MDSC.
→ RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol
→ ANGIOGENESIS@default
→ trILB1@INNATE_IMMUNE_CELL_Cytosol
+ IL1R1:IL1RAP@INNATE_IMMUNE_CELL_Membrane → IL1R1:IL1RAP:trILB1@INNATE_IMMUNE_CELL_Membrane
→ trILB1@default