Phenotype ANGIOGENESIS map
ANGIOGENESIS@default

References
PMID:18633355
Hypoxic macrophages are known to respond to hypoxia by upregulating hypoxia-inducible transcription factors (mainly hypoxia-inducible factors HIF1 and HIF2)38, 39, the activation of which leads to increased transcription of many genes that regulate cell proliferation, metabolism and angiogenesis40.
Hypoxia induces a distinct pro-angiogenic phenotype in human macrophages in vitro42, 43 including the upregulation of VEGF, bFGF, CXCL8, COX2, hepatocyte growth factor (HGF), VEGFR1, tissue factor (F3) and MMP12.

Modifications:
In compartment: default
  1. ANGIOGENESIS@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. VEGFA@default map → map ANGIOGENESIS@default map
    2. IL1A@default map → map ANGIOGENESIS@default map
    3. trILB1@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    4. IL8*@default map → map ANGIOGENESIS@default map
    5. TYMP@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    6. FGF2@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    7. HGF@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    8. MMP12@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    9. CXCL1@default map → map ANGIOGENESIS@default map
    10. OSM@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    11. ADM@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    12. WNT7B@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    13. PLAU@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    14. PDGFB@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    15. Heparin@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    16. NGF@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    17. MMP9@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    18. Histamine@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    19. ANGIOGENESIS@default map → map TUMOR_GROWTH@TUMOR_CELL_AS_EFFECTOR map
    20. Hypoxia@TUMOR_CELL_AS_INDUCTOR map → map ANGIOGENESIS@default map
    21. TNF@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    As Catalyser: