Protein PDGFB map

Identifiers
HGNC:8800
platelet-derived growth factor beta polypeptide
HUGO:PDGFA HGNC:8800 ENTREZ:5155 UNIPROT:P01127
HUGO:PDGFB

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:17145802
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910
 MACROPHAGE  map
 MAST_CELL  map
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
PMID:24359404
PDGF signaling drives tumor growth
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization, histamine, which is an immunosuppressant,
mitogenic factors, such as platelet-derived
growth factor (PDGF), nerve GF (NGF), stem-cell factor
(SCF), and proteases, which disrupt the surrounding
matrix and facilitate metastases.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDGFB@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PDGFB@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    2. PDGFB@INNATE_IMMUNE_CELL_Cytosol map → map TUMOR_GROWTH@TUMOR_CELL_AS_EFFECTOR map
    As Catalyser: