Identifiers
matrix metallopeptidase 9
HUGO:MMP9 hgnc_id:HGNC:7176 HGNC:7176 ENTREZ:4318 UNIPROT:P14780
HUGO:MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
HUGO:MMP9, HGNC:7176, ENTREZ:4318, UNIPROT:P14780, GENECARDS:GC20P044637??
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MATRIX_REGULATION
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
Innate Immunity / TUMOR_GROWTH
References
PMID:19847259
In fibroblasts PTEN inhibit ETS2 expression; and AKT and JNK induce phosphorylqtion of ETS2. MMP9 and CCL3 are the direct targets of this transcription factor.
PMID:11875494
MMPs plays important in the degradation and remodeling of the
extracellular matrix at sites of inflammation. HMOX1 (HO1) mediates IL-10-induced suppression
of MMP9 expression.
PMID:18633355
MMP7, MMP9 and MMP12 from macrophages drives angiogenesis
MDSC isolated from murine tumours express higher levels of various MMPs (MMP2, MMP9, MMP13 and MMP14 than MDSC from healthy mice
PMID:23390297, PMID:22461508
MIF signaling induces angiogenesis probavly via upregulation of MMP9, VEGF expression in macrophages and activates tumor invasion
PMID:21896641
mast cells and mast
cell derived MMP-9 contribute to the development of
well-differentiated prostate tumors
PMID:22425643
A key mediator secreted from neutrophils and involved in carcinogenesis
is MMP-9. It was demonstrated to be involved in skin tumorigenesis,
by regulation of oncogene-induced keratinocyte hyperproliferation
and their progression to invasive cancer (71). In addition to its effects
on matrix, it has been shown that MMP-9 secreted from neutrophils
(among other bone marrow cells) prevents apoptosis of tumor cells in
the lung (72).
→ MATRIX_REMODELLING@default
→ ANGIOGENESIS@default
→ MMP9@INNATE_IMMUNE_CELL_Cytosol