Protein MMP12 map

Identifiers
matrix metallopeptidase 12 (macrophage elastase)
"matrix metalloproteinase 12 (macrophage elastase)"
HUGO:MMP12 HGNC:7158 ENTREZ:4321 UNIPROT:P39900
HUGO:MMP12

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / TUMOR_GROWTH  map

References
 MACROPHAGE  map
PMID:22880008
Classical activation of macrophages derived in vitro from un-fractionated CD16(+/-) or negatively-selected CD16(-) macrophages up-regulated MMP-1, -3, -7, -10, -12, -14 and -25 and decreased TIMP-3 steady-state mRNA levels.
By contrast, alternative activation decreased MMP-2, -8 and -19 but increased MMP -11, -12, -25 and TIMP-3 steady-state mRNA levels. Up-regulation of MMPs during classical activation depended on mitogen activated protein kinases, phosphoinositide-3-kinase and inhibitor of ??B kinase-2. Effects of interferon?? depended on janus kinase-2.
PMID:18633355
MMP7, MMP9 and MMP12 drives angiogenesis

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. MMP12@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MMP12@INNATE_IMMUNE_CELL_Cytosol map → map MATRIX_REMODELLING@default map
    2. MMP12@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
    As Catalyser: