Protein CXCL1 map

Identifiers
C-X-C motif chemokine ligand 1
HUGO:CXCL1 hgnc_id:HGNC:4602 HGNC:4602 ENTREZ:2919 UNIPROT:P09341
HUGO:CXCL1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
CASCADE:IL1
PMID:23567181
inhibition of NF-??B signaling, driving expression of CXCL1 and CXCL2 in skin CAFs resulted in decreased macrophage infiltration into transplanted skin tumors, and reduced tumor growth, indicating a central role for CAFs in facilitating the trafficking of macrophages into tumors
PMID:18633355
Release of the pro-angiogenic chemokines CXCL8 and CXCL1 by neutrophils is also triggered by TNF, and by granulocyte-macrophage colony-stimulating factor (GM-CSF, CSF2), platelet-activating factor and CXCL8 itself

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. CXCL1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. CXCL1@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CXCL1@INNATE_IMMUNE_CELL_Cytosol map → map CXCL1@default map
    2. CXCL1@default map → map ANGIOGENESIS@default map
    As Catalyser: