IL8*

Protein IL8*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / RECRUITMENT_OF_IMMUNE_CELLS
Innate Immunity / TUMOR_GROWTH

References
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
Release of the pro-angiogenic chemokines CXCL8 and CXCL1 by neutrophils is also triggered by TNF, and by granulocyte-macrophage colony-stimulating factor (GM-CSF, CSF2), platelet-activating factor and CXCL8 itself
iDC in ovarian cancer ascites promote angiogenesis in vivo through production of TNF and CXCL8
PMID:18980965
Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human
neutrophils
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization,

IL8*@INNATE_IMMUNE_CELL_Cytosol

References
in_re556( Innate Immunity ):
PMID:16878026, PMID:10952726
HMGB1 induces IL8 secretion probably via NFkB.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol

IL8*@INNATE_IMMUNE_CELL_Cytosol

In compartment: default

IL8*@default

Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser: