Phenotype Hypoxia map
Hypoxia@TUMOR_CELL_AS_INDUCTOR

References
 NATURAL_KILLER  map
PMID:25277195, PMID:22006996, PMID:25103413
Hypoxia down-regulates level of MICA, MICB, ULBP2 and ULBP3 transcripts in tumors
and reduces the sensitivity of tumor cell lines against NK cell-mediated lysis
PMID:22006996, PMID:19704417
Hypoxia prevents HIF1A degradation and induces accumulation of HIF1A
in tumor cells.
PMID:25103413
Hypoxia downregulates HSP70 level in membrane.
PMID:18633355
Hypoxic macrophages are known to respond to hypoxia by upregulating hypoxia-inducible transcription factors (mainly hypoxia-inducible factors HIF1 and HIF2)38, 39, the activation of which leads to increased transcription of many genes that regulate cell proliferation, metabolism and angiogenesis40.
Hypoxia induces a distinct pro-angiogenic phenotype in human macrophages in vitro42, 43 including the upregulation of VEGF, bFGF, CXCL8, COX2, hepatocyte growth factor (HGF), VEGFR1, tissue factor (F3) and MMP12.

Modifications:
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. Hypoxia@TUMOR_CELL_AS_INDUCTOR map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Hypoxia@TUMOR_CELL_AS_INDUCTOR map → map ANGIOGENESIS@default map
    2. Hypoxia@TUMOR_CELL_AS_INDUCTOR map → map lactic acid @default map
    As Catalyser:
    1. gULBP2@TUMOR_CELL_AS_INDUCTOR map → map rULBP2@TUMOR_CELL_AS_INDUCTOR map
    2. gMICA@TUMOR_CELL_AS_INDUCTOR map → map rMICA@TUMOR_CELL_AS_INDUCTOR map
    3. gMICB@TUMOR_CELL_AS_INDUCTOR map → map rMICB@TUMOR_CELL_AS_INDUCTOR map
    4. gUDLP3@TUMOR_CELL_AS_INDUCTOR map → map rUDLP3@TUMOR_CELL_AS_INDUCTOR map
    5. HIF1A@TUMOR_CELL_AS_INDUCTOR map → map degraded
    6. HIF1A@TUMOR_CELL_AS_INDUCTOR map → map HIF1A@TUMOR_CELL_AS_INDUCTOR map
    7. HSP70*@TUMOR_CELL_AS_INDUCTOR map → map HSP70*@default map
    8. HIF2A*@INNATE_IMMUNE_CELL_Cytosol map → map HIF2A*@INNATE_IMMUNE_CELL_Cytosol map
    9. HIF1A@INNATE_IMMUNE_CELL_Cytosol map → map HIF1A@INNATE_IMMUNE_CELL_Cytosol map