Protein HIF1A map

Identifiers
HUGO:SETD2 HGNC:18420
HUGO:HIF1A
hypoxia inducible factor 1 alpha subunit
HUGO:HIF1A hgnc_id:HGNC:4910 HGNC:4910 ENTREZ:3091 UNIPROT:Q16665
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HUGO:HIF1A, HGNC:4910, ENTREZ:3091, GENECARDS:GC14P062162, UNIPROT:Q16665
HUGO:HIF1A HGNC:4910 ENTREZ:3091 UNIPROT:Q16665

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / RCD_GENES  map
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map
 Innate Immunity  map  / MIRNA_TF_IMMUNOSUPPRESSIVE  map

References
PMID:10804084
PMID:16110315 PMID:22988108
CASCADE:TGFB
PMID:22850421
Protein level of MCT4 (SLC16A4) in CAFs is redox and HIF1 dependent.
PMID:20855962
HIF-1?? drives Cav-1 degradation in CAFs and provides CAFs autophagy
Autophagy in cancer associated fibroblasts promotes tumor cell survival:
PMID:21051947
fibroblasts expressing activated HIF1?? increased tumor mass by ???2-fold and tumor volume by ???3-fold, without an increase in angiogenesis.5 Similarly, HIF1??-transfected fibroblasts increased the lymph node metastasis of cancer cells.
PMID:20535745
junD???/??? fibroblasts exhibit features of carcinoma-associated myofibroblasts.
The expression of the chemokine CXCL12 was increased in junD???/??? fibroblasts
HIF-1?? protein accumulates in junD???/??? fibroblasts and mice (Gerald et al, 2004; Laurent et al, 2008), the up-regulation of CXCL12 in junD???/??? fibroblasts could be mediated, at least partly, through HIF. Specific inhibition of HIF-1?? by siRNA strongly reduced HIF-1?? mRNA levels (Fig S3A) and decreased the expression of its target gene, CXCL12
PMID:25732824
expression of HIF-1?? was increased in CAFs, with no significant changes for HIF-2?? or HIF-3??
Stabilization of HIF-1?? protein in induced CAF cells downstream of tgfb 5mRNA level is the same)
The gene HIF1A gives rise to 3 different isoforms: HIF1_alpha_, HIF2_alpha_ and HIF3_alpha
PMID:17533374
HIF-1 and NF-kappaB upregulates CXCR1 and CXCR2 expression
 NATURAL_KILLER  map
 MACROPHAGE  map
CASCADE:IL4
CASCADE:LACTIC
CASCADE:IL13
CASCADE:CSF2
CASCADE:IFNG
PMID:22006996
Hypoxia-induced expression of ADAM10 is HIF-1-dependent.
PMID:25103413
Hypoxia downregulates MICA, MICB surface expression via HIF1A.
PMID:24006507
HIF1A expression is assotiated with classical activation of macrophages
PMID:20427344
HIF1 expression is assotiated with classical activation of macrophages
HIF1A upregulates expression of: TNF, IL6, HIF1A downregulates expression of M2 markers CD206 and STAB1.
PMID_24006507
IL4 downregulates HIF1a translation.
PMID:21765015
CSF2 upregulates VEGF expression via HIF1a specific inhibition of PHD2 increases VEGF production
HIF1a induces MIF expression of macrophages after hypoxia.
IL4+IL13 inhibit MIF expression via inhibition of HIF1a expression.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia??in vitro??and by TAMs in hypoxic/necrotic areas of human tumors.
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1??.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
HIF1A upregulates expression of: TNF, IL6 and downregulates expression of M2 markers CD206 and STAB1
HIF1A upregulates expression of EGLN1, EGLN3, PDK1, Pfkfb3, GLUT1, VEGF, FGF2 Mif, Ccr2, Cxcl2

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. HIF1A@INNATE_IMMUNE_CELL_Cytosol map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. HIF1A@TUMOR_CELL_AS_INDUCTOR map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. HIF1A@TUMOR_CELL_AS_INDUCTOR map → map degraded
    2. HIF1A@TUMOR_CELL_AS_INDUCTOR map → map HIF1A@TUMOR_CELL_AS_INDUCTOR map
    3. rHIF1A@INNATE_IMMUNE_CELL_Cytosol map → map HIF1A@INNATE_IMMUNE_CELL_Cytosol map
    4. HIF1A@INNATE_IMMUNE_CELL_Cytosol map → map HIF1A@INNATE_IMMUNE_CELL_Cytosol map
    5. HIF1A@INNATE_IMMUNE_CELL_Cytosol map → map degraded
    As Catalyser:
    1. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
    2. gMIF@INNATE_IMMUNE_CELL_Cytosol map → map rMIF@INNATE_IMMUNE_CELL_Cytosol map
    3. gMICB@TUMOR_CELL_AS_INDUCTOR map → map rMICB@TUMOR_CELL_AS_INDUCTOR map
    4. gADAM10@TUMOR_CELL_AS_INDUCTOR map → map rADAM10@TUMOR_CELL_AS_INDUCTOR map
    5. gARG1@INNATE_IMMUNE_CELL_Cytosol map → map rARG1@INNATE_IMMUNE_CELL_Cytosol map
    6. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
    7. gVEGFA@INNATE_IMMUNE_CELL_Cytosol map → map rVEGFA@INNATE_IMMUNE_CELL_Cytosol map