Identifiers
HUGO:IL6
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
References
PMID:27557510
CASCADE:TGFB
CASCADE:IL1
PMID:23034983
TGFB upregulates gene expression of CAF markers ,??FSP1 (S100A4), and??TNC. (provably via SMAD3), and gene expression of CCL5, SDF1(CXCL12), BMP4, IL6, CXCL7, IL6R, IL6ST, CXCL5
PMID:20138012
PTGS2, CXCL1, and CXCL2; the proinflammatory cytokines IL-1?? and IL-6, CYR61 and OPN are upregulated in CAFs,
probably downstream of IL1B via NFkB
PMID:24857661
TGF-??1-stimulated hDF was thus assessed by quantitative real-time PCR, that disclosed a 100-fold increase of LIF and 5-fold increase of IL6 mRNA steady-state levels.
CASCADE:PGE
PMID:8133053
IL1a and TGFB induce IL6 gene expression and protein accamulation in fibroblasts.
PMID:18555778
In response to oncogenic stress, both IL6 and IL8 genes were activatedbythe transcription factorC/EBPb,upon its recruitment to either promoter.
PMID:18555777
There is a positive feedback loop between IL6 and CEBP that help maintain the senescence state
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:15749903, PMID:16413922
NFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
and inhibit IL6 expression.
PMID:9743347
IL-13 blocks NF-??B-dependent production of IL6
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:20093776
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells via TLR2/MyD88 dependent IL6 expression.
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
mRNA expression of several NF-??B target genes such is IL6, IL1B,TNF are IL1B/NFkB dependent in MSDC
PMID:17942936
IL-6 is a downstream mediator of the IL-1beta-induced expansion of MDSC
PMID:17485448, PMID:10542212
Inhibition of NfkB signaling downstream of ABIN3 inhibits expression of IL8, IL6, TNFa, IL12p40
PMID:??23986532
STING ablation abolished hallmark TGF-?? and IL-10 regulatory cytokine induction (mRNA)by apoptotic cells, and proinflammatory IL-6 mRNA was expressed instead in DCs
References
in_re560( Innate Immunity ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:15749903, PMID:16413922
NFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
and inhibit IL6 expression.
PMID:9743347
IL-13 blocks NF-??B-dependent production of IL6
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.