Catalysis

1. HIF1A@INNATE_IMMUNE_CELL_Cytosol
2. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane

Inhibition

1. IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol
2. STING*@INNATE_IMMUNE_CELL_Cytosol
3. IRF4@INNATE_IMMUNE_CELL_Cytosol

References
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:15749903, PMID:16413922
NFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
and inhibit IL6 expression.
PMID:9743347
IL-13 blocks NF-??B-dependent production of IL6
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.