Complex CD14:IRAK2:IRAK4:LY96:MYD88:TIRAP:TLR2/4* map
Complex composition:

  1. CD14 map
  2. IRAK4 map
  3. TLR2/4* map
  4. LY96 map
  5. MYD88 map
  6. TIRAP map
  7. IRAK2 map

CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:CD14:IRAK2:IRAK4:LY96:MYD88:TIRAP:TLR2/4*

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:14660645, PMID:16878026, PMID:23681101
The adaptor proteins MyD88 and TIRAP associate with TLR 2 and TLR 4 after receptor engagement.
Transfection of dominant negative MyD88 or TIRAP inhibited almost all of the HMGB1- and LPS-induced NF-??B activation.
MyD88 recruits members of the death domain-containing serine/threonine IL-1R-associated kinase (IRAK) family.
PMID:12620219
MyD88 mediates a close interaction of the two related IRAK molecules,
which is essential to allow IRAK-4 to phosphorylate IRAK-1. Phosphorylation of IRAK-1
reduces its affinity for MyD88, while increasing its affinity for TRAF6
PMID:21372296
HMGB1 induces the production of angiogenic factors VEGF, and TGFB1 by macrophage via TLR4-dependent mechanisms.
in_re423( Innate Immunity  map ):
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.
in_re560( Innate Immunity  map ):
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12
PMID:15749903, PMID:16413922
NFKBID (IkBNS) interacts with NFkB p50 inhibit recrutement NFkB p50/p65 to IL-6 promoter
and inhibit IL6 expression.
PMID:9743347
IL-13 blocks NF-??B-dependent production of IL6
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
in_re573( Innate Immunity  map ):
PMID:16127449
PPARG sumoilated by PIAS1/UbC9 prevents dissociation of the NCoR???HDAC3 complex fro promoters and transrepresses expression NOS2, Ccl3, Ccl7, Cxcl10
in_re580( Innate Immunity  map ):
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
in_re1088( Innate Immunity  map ):
PMID:12907458
IL10 induces SOCS3 expression in STAT3 dependent manner.

Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IRAK2@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. CCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@default map
  2. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
  3. TGFB*@INNATE_IMMUNE_CELL_Cytosol map → map TGFB*@default map
  4. CCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@default map
  5. VEGFA@INNATE_IMMUNE_CELL_Cytosol map → map VEGFA@default map
  6. CXCL2@INNATE_IMMUNE_CELL_Cytosol map → map CXCL2@default map
  7. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
  8. TIMP2@INNATE_IMMUNE_CELL_Cytosol map → map TIMP2@INNATE_IMMUNE_CELL_Membrane map
  9. TIMP1@INNATE_IMMUNE_CELL_Cytosol map → map TIMP1@INNATE_IMMUNE_CELL_Membrane map
  10. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  11. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
  12. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
  13. gCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL10@INNATE_IMMUNE_CELL_Cytosol map
  14. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  15. IRAK1@INNATE_IMMUNE_CELL_Cytosol map → map IRAK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  16. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map